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Sex, aging, immunity and adrenal cancer

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Warde and colleagues demonstrate sex-specific differences in senescence in the adrenal glands of aged mice, with males eliciting a more robust, protective myeloid response that is associated with protection from adrenal cancer.

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Fig. 1: Sex regulates the extent of aging-induced senescence in the adrenal gland with stronger myeloid signatures in male mice being associated with protection from adrenal cancer.

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Acknowledgements

We thank A. A. Henry and C. C. Porter for their review of an early draft of this work.

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A.T. assisted with the drafting of this manuscript, reviewed the manuscript and created the original Fig. 1. C.J.H. conceptualized the format of this article, drafted the article, assisted with the design of the original Fig. 1 and approved the final draft of this work.

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Correspondence to Curtis J. Henry.

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The authors declare no competing interests.

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Townsel, A., Henry, C.J. Sex, aging, immunity and adrenal cancer. Nat Aging 3, 764–765 (2023). https://doi.org/10.1038/s43587-023-00440-y

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