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Immune modulation by MANF improves regeneration in aged skeletal muscle

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Despite the central role of immune regulation in tissue repair, the contribution of immune dysfunction to regenerative failure in aging is mostly unknown. We discovered a mechanism of immune modulation that operates during skeletal muscle regeneration that is compromised in aged animals and can be harnessed to improve regenerative capacity in aging.

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Fig. 1: MANF loss in aging impairs skeletal muscle regeneration.

References

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This is a summary of: Sousa, N. S. et al. Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration. Nat. Aging https://doi.org/10.1038/s43587-023-00382-5 (2023).

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Immune modulation by MANF improves regeneration in aged skeletal muscle. Nat Aging 3, 477–478 (2023). https://doi.org/10.1038/s43587-023-00411-3

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  • DOI: https://doi.org/10.1038/s43587-023-00411-3

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