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GDF11 reverses mood and memory declines in aging

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Aging is known to be associated with a decline in memory and mood, but the molecular mechanisms that underlie these changes remain unclear. Moigneu, Abdellaoui and colleagues show that growth differentiation factor 11 reverses deficits in these functions in aged mice, pointing the way towards a novel pro-mnemonic and antidepressant therapeutic target.

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Fig. 1: GDF11 supplementation reverses age-related deficits in mood and memory.

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Acknowledgements

P.P. and A.H. are supported by the NIAAA Intramural Research Program.

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Authors and Affiliations

  1. Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA

    Patrick T. Piantadosi & Andrew Holmes

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  1. Patrick T. Piantadosi
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  2. Andrew Holmes
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Correspondence to Andrew Holmes.

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The authors declare no competing interests.

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Piantadosi, P.T., Holmes, A. GDF11 reverses mood and memory declines in aging. Nat Aging 3, 148–150 (2023). https://doi.org/10.1038/s43587-023-00362-9

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