Under conditions of stress, autophagic degradation of nuclear and nucleolar components was found to promot.e youthfulness and delay aging by preserving nuclear architecture and preventing nucleolar expansion, in somatic cells. We also found that nuclear-material autophagy serves as an essential quality-control mechanism that contributes to sustaining germline immortally.
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This is a summary of: Papandreou, M.-E., Konstantinidis, G. & Tavernarakis, N. Nucleophagy delays aging and preserves germline immortality. Nat. Aging https://doi.org/10.1038/s43587-022-00327-4 (2022).
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Nuclear autophagy promotes longevity and germline immortality. Nat Aging 3, 11–12 (2023). https://doi.org/10.1038/s43587-022-00336-3
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DOI: https://doi.org/10.1038/s43587-022-00336-3
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