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Bone aging

Skin and bone crosstalk during aging

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A new study shows that decreased cystatin A synthesis in aged epidermis mediates age-related bone loss, whereas topical treatment that restores cystatin A mitigates this loss. This report demonstrates that skin aging has systemic consequences by showing that signals originating in skin can control bone function.

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Fig. 1: Changes associated with skin aging and possible mechanisms linking them with systemic age-related disease.

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Authors and Affiliations

  1. Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA

    Theodora Mauro

  2. San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA

    Theodora Mauro

  3. Departments of Medicine and Dermatology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA, USA

    Daniel Bikle

Authors
  1. Theodora Mauro
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  2. Daniel Bikle
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Correspondence to Theodora Mauro or Daniel Bikle.

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The authors declare no competing interests.

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Mauro, T., Bikle, D. Skin and bone crosstalk during aging. Nat Aging 2, 874–875 (2022). https://doi.org/10.1038/s43587-022-00295-9

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