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BRAIN AGING

Astrocytic traffic jams in the aging brain

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Lee and colleagues reveal a previously unrecognized population of astrocytes in the aged brain with disrupted proteostatic signaling that generates defects in astrocyte morphology, protein trafficking and synapse maintenance in the aging hippocampus.

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Fig. 1: A genetically and functionally unique population of hippocampal astrocytes stemming from reduced astrocytic mTOR and proteasome activity appears with advancing age.

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Author information

Authors and Affiliations

  1. Department of Cell Biology, Duke University Medical Center, Durham, NC, USA

    Ryan Baumert, Nicholas Brose & Cagla Eroglu

  2. Department of Neurobiology, Duke University Medical Center, Durham, NC, USA

    Cagla Eroglu

  3. Duke Institute for Brain Sciences (DIBS), Durham, NC, USA

    Cagla Eroglu

  4. Howard Hughes Medical Institute, Duke University, Durham, NC, USA

    Cagla Eroglu

Authors
  1. Ryan Baumert
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  2. Nicholas Brose
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  3. Cagla Eroglu
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Corresponding author

Correspondence to Cagla Eroglu.

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The authors declare no competing interests.

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Baumert, R., Brose, N. & Eroglu, C. Astrocytic traffic jams in the aging brain. Nat Aging 2, 681–683 (2022). https://doi.org/10.1038/s43587-022-00270-4

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