Mouse frailty can be measured with a frailty index by manually counting health deficits. Vivek Kumar and colleagues use machine learning to extract physical performance deficits from video data to create a ‘visual frailty index’. This automated technique may facilitate high-throughput research into new frailty interventions.
References
Vaupel, J. W., Manton, K. G. & Stallard, E. Demography 16, 439–454 (1979).
Howlett, S. E., Rutenberg, A. D. & Rockwood, K. Nat. Aging 1, 651–665 (2021).
Mitnitski, A. B., Mogilner, A. J. & Rockwood, K. ScientificWorldJournal 1, 323–336 (2001).
Whitehead, J. C. et al. J. Gerontol. A Biol. Sci. Med. Sci. 69, 621–632 (2014).
Kane, A. E. et al. J. Gerontol. A Biol. Sci. Med. Sci. 70, 694–695 (2015).
Feridooni, H. A., Sun, M. H., Rockwood, K. & Howlett, S. E. J. Gerontol. A Biol. Sci. Med. Sci. 70, 686–693 (2015).
Kane, A. E., Ayaz, O., Ghimire, A., Feridooni, H. A. & Howlett, S. E. Can. J. Physiol. Pharmacol. 95, 1149–1155 (2017).
Hession, L. E., Sabnis, G. S., Churchill, G. A. & Kumar, V. Nat. Aging https://doi.org/10.1038/s43587-022-00266-0 (2022).
Mach, J. et al. Exp. Gerontol. 161, 111700 (2022).
Fielder, E. et al. eLife 11, e75492 (2022).
Keller, K., Kane, A., Heinze-Milne, S., Grandy, S. A. & Howlett, S. E. J. Gerontol. A Biol. Sci. Med. Sci. 74, 1149–1157 (2019).
Yu, D. et al. Cell Rep. 29, 236–248.e3 (2019).
Bisset, E. S., Heinze-Milne, S., Grandy, S. A. & Howlett, S. E. J. Gerontol. A Biol. Sci. Med. Sci. 77, 41–46 (2022).
Seibenhener, M. L. & Wooten, M. C. JoVE 96, e52434 (2015).
Kane, A. E. & Howlett, S. E. Mech. Ageing Dev. 198, 111546 (2021).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Bisset, E.S., Howlett, S.E. Machine learning to spot frailty in aging mice. Nat Aging 2, 684–685 (2022). https://doi.org/10.1038/s43587-022-00267-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43587-022-00267-z
- Springer Nature America, Inc.