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NEURODEGENERATION

Gut mitochondrial defects drive neurodegeneration

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Neurodegenerative diseases, including Parkinson’s disease, are linked to the accumulation of defective mitochondria in the brain and to microbial dysbiosis in the gut. However, the interplay between these factors is incompletely understood. Fedele et al. reveal how gut mitochondrial dysfunction activates intestinal inflammation to drive neurodegeneration in a Parkinson’s disease model.

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Fig. 1: Activation of the immune response in intestinal cells, due to mitochondrial dysfunction, is required for neurotoxicity in a Drosophila model of PD.

References

  1. Fung, T. C., Olson, C. A. & Hsiao, E. Y. Nat. Neurosci. 20, 145–155 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Fedele, G. et al. Nat. Aging https://doi.org/10.1038/s43587-022-00194-z (2022).

    Article  Google Scholar 

  3. Pickrell, A. M. & Youle, R. J. Neuron 85, 257–273 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kim, S. et al. Neuron 103, 627–641 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sliter, D. A. et al. Nature 561, 258–262 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Buchon, N., Silverman, N. & Cherry, S. Nat. Rev. Immunol. 14, 796–810 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Rera, M., Clark, R. I. & Walker, D. W. Proc. Natl Acad. Sci. USA 109, 21528–21533 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Clark, R. I. et al. Cell Rep. 12, 1656–1667 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Pérez-Treviño, P., Velásquez, M. & García, N. Biochim. Biophys. Acta Mol. Basis Dis. 1866, 165761 (2020).

    Article  PubMed  Google Scholar 

  10. West, A. P. & Shadel, G. S. Nat. Rev. Immunol. 17, 363–375 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Matsui, H. et al. Nat. Commun. 12, 3101 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Liu, X. et al. PLoS ONE 7, e42725 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Okabe, Y., Sano, T. & Nagata, S. Nature 460, 520–524 (2009).

    Article  CAS  PubMed  Google Scholar 

  14. Shen, Y., Huang, J. Y., Li, J. & Liu, C. F. Chin. Med. J. 131, 974–981 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Julienne, H., Buhl, E., Leslie, D. S. & Hodge, J. J. L. Neurobiol. Dis. 104, 15–23 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

D.W.W. is supported by NIH grants R01AG037514 and RF1AG049157.

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Authors and Affiliations

  1. Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA

    Ricardo Aparicio, Edward T. Schmid & David W. Walker

  2. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA

    David W. Walker

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  1. Ricardo Aparicio
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  2. Edward T. Schmid
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  3. David W. Walker
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Correspondence to Ricardo Aparicio or David W. Walker.

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The authors declare no competing interests.

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Aparicio, R., Schmid, E.T. & Walker, D.W. Gut mitochondrial defects drive neurodegeneration. Nat Aging 2, 277–279 (2022). https://doi.org/10.1038/s43587-022-00206-y

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