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Apolipoprotein E regulates chromatin stability and senescence

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Apolipoprotein E (APOE) is an important regulator of lipid metabolism and is genetically associated with longevity and age-related diseases such as Alzheimer’s disease. However, the molecular mechanisms that link APOE and aging are incompletely understood. Now an article in Nature Aging reveals that nuclear APOE promotes senescence by destabilizing heterochromatin.

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Fig. 1: APOE promotes MPC senescence through disrupting heterochromatin.

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Acknowledgements

L.W. is supported by National Institute on Aging grant K99AG065500. Z.D. is supported by National Institute of Health grants R35GM137889, R00AG053406, UG3CA268117, Glenn Foundation for Medical Research and AFAR, and Longevity Impetus Grant.

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Lu Wang

  2. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA

    Zhixun Dou

  3. Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA

    Zhixun Dou

  4. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Zhixun Dou

Authors
  1. Lu Wang
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  2. Zhixun Dou
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Correspondence to Lu Wang or Zhixun Dou.

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The authors declare no competing interests.

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Wang, L., Dou, Z. Apolipoprotein E regulates chromatin stability and senescence. Nat Aging 2, 282–284 (2022). https://doi.org/10.1038/s43587-022-00190-3

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