The scaling up of a chemical reaction is a complex process. Chemists should pay special attention to a number of key factors, including the choice of route, reagents and solvents; health and safety considerations; the isolation and purification of the desired product; and the development of robust supporting analytical methodology.
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Hitchin, J.R. The scale up of chemical reactions. Nat Rev Methods Primers 2, 28 (2022). https://doi.org/10.1038/s43586-022-00116-8
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DOI: https://doi.org/10.1038/s43586-022-00116-8
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