Autotaxin (ATX) produces lysophosphatidic acid (LPA), which directly promotes pancreatic ductal adenocarcinoma (PDAC) growth, but the role of the tumor microenvironment (TME) in ATX-driven tumor growth is unclear. ATX–LPA signaling in PDAC is now shown to shape the TME by inhibiting eosinophil recruitment, resulting in increased tumor growth.
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Grisaru-Tal, S., Munitz, A. ATX restricts anti-tumor eosinophil responses. Nat Cancer 5, 221–223 (2024). https://doi.org/10.1038/s43018-023-00718-5
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DOI: https://doi.org/10.1038/s43018-023-00718-5
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