Chromosomal instability (CIN) (a hallmark of human cancer) is caused by persistent errors in chromosome segregation during mitosis. Pharmacological inhibition of the mitotic kinesin KIF18A selectively exploits a mitotic vulnerability for which cancer models with CIN are enriched, which leads to robust anti-cancer effects and durable tumor regression in mice.
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References
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This is a summary of: Payton, M. et al. Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nat. Cancer https://doi.org/10.1038/s43018-023-00699-5 (2023).
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Therapeutic targeting of the KIF18A motor protein in cancers with chromosomal instability. Nat Cancer 5, 10–11 (2024). https://doi.org/10.1038/s43018-023-00700-1
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DOI: https://doi.org/10.1038/s43018-023-00700-1
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