Cancer cells seed distant tissues and remain dormant before re-entering the cell cycle to form metastases. How tumor dormancy is maintained and how cells exit dormancy is poorly understood. A study shows that the lncRNA MALAT1 reactivates dormant cancer cells by upregulating serpin protease inhibitors in tumor cells to evade CD8+ T cells.
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This manuscript was supported by US National Institutes of Health grant R01CA240955 (J.L.).
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Zhang, Z., Lieberman, J. MALAT1 protects dormant tumor cells from immune elimination. Nat Cancer 5, 218–220 (2024). https://doi.org/10.1038/s43018-023-00682-0
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DOI: https://doi.org/10.1038/s43018-023-00682-0
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