This study reveals the previously underappreciated roles of CD25 (IL-2 receptor subunit-α) in IL-2 biology and cancer immunotherapy and provides mechanistic insights into the rational design of more-effective IL-2-based therapeutic agents for cancer treatment.
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This is a summary of: Wu, W. et al. IL-2Rα-biased agonist enhances antitumor immunity by invigorating tumor-infiltrating CD25+CD8+ T cells. Nat. Cancer https://doi.org/10.1038/s43018-023-00612-0 (2023).
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‘IL-2Rα-biased’ IL-2 for cancer immunotherapy. Nat Cancer 4, 1222–1223 (2023). https://doi.org/10.1038/s43018-023-00613-z
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DOI: https://doi.org/10.1038/s43018-023-00613-z
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