Persistent senescent cancer cells have tumor-promoting potential, making their selective elimination a prime therapeutic objective. The death receptor inhibitor cFLIP has now been shown to counter the susceptibility of senescent cells to DR5-mediated extrinsic apoptosis, which can be therapeutically exploited.
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Fan, D.N.Y., Schmitt, C.A. A cFLIP-flop switch for senolysis. Nat Cancer 3, 1279–1281 (2022). https://doi.org/10.1038/s43018-022-00455-1
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DOI: https://doi.org/10.1038/s43018-022-00455-1
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