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TUMOR IMMUNOLOGY

DePICting T cell–APC crosstalk in cancer

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Cellular communication in the tumor microenvironment is crucial for T cell activation; however, the molecular features of the T cell–antigen-presenting cell interaction are still poorly understood. A new study utilizes RNA sequencing of physically interacting cells to reveal that PD-1+CXCL13+ helper T cells in tumors, primed by dendritic cells, are important for the response to immunotherapy.

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Fig. 1: Tht cells, identified by PIC-seq in human lung tumors, facilitate the immune response to anti-PD-1 immunotherapy.

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Authors and Affiliations

  1. Shanghai Immune Therapy Institute, Shanghai Jiaotong University School of Medicine-affiliated Renji Hospital, Shanghai, China

    Ting Zhang & Chen Dong

  2. Institute of Immunology and School of Medicine, Tsinghua University, Beijing, China

    Chen Dong

Authors
  1. Ting Zhang
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  2. Chen Dong
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Correspondence to Chen Dong.

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Zhang, T., Dong, C. DePICting T cell–APC crosstalk in cancer. Nat Cancer 3, 265–267 (2022). https://doi.org/10.1038/s43018-022-00345-6

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