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TUMOR MICROENVIRONMENT

2-HG modulates glioma macrophages via Trp metabolism

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Immuno-oncology approaches have shown little efficacy against high-grade glioma, a devastating manifestation of brain cancer. A new study now finds a metabolic vulnerability in IDH1-mutant glioma that can be targeted to reprogram tumor-infiltrating macrophages and create a tumor microenvironment that is more responsive to immune-checkpoint therapy.

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Fig. 1: IDH1-mutant HGGs drive infiltrating monocyte-derived macrophages to a tolerogenic phenotype via activation of the AhR signaling pathway.

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Authors and Affiliations

  1. Tumor Immunotherapy Program, The Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada

    Marie Jo Halaby & Tracy L. McGaha

  2. Department of Immunology, The University of Toronto, Toronto, Ontario, Canada

    Tracy L. McGaha

Authors
  1. Marie Jo Halaby
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  2. Tracy L. McGaha
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Correspondence to Tracy L. McGaha.

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The authors declare no competing interests.

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Halaby, M.J., McGaha, T.L. 2-HG modulates glioma macrophages via Trp metabolism. Nat Cancer 2, 677–679 (2021). https://doi.org/10.1038/s43018-021-00231-7

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