Shedding light on the mechanisms that underlie a durable response to immunotherapy, a recent study evaluating long-term survivors of melanoma treated with immunotherapy finds that tumor-associated T cell clonotypes are sustained over years and persist as expanded, cytokine IFN-γ–expressing resident memory T cells in the skin, with effector memory counterparts in the blood.
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References
Wherry, E. J. Nat. Immunol. 12, 492–499 (2011).
Sharma, P. & Allison, J. P. Cell 161, 205–214 (2015).
Topalian, S. L. et al. N. Engl. J. Med. 366, 2443–2454 (2012).
Chen, P. L. et al. Cancer Discov. 6, 827–837 (2016).
Huang, A. C. et al. Nature 545, 60–65 (2017).
Sade-Feldman, M. et al. Cell 175, 998–1013.e1020 (2018).
Riaz, N. et al. Cell 171, 934–949.e916 (2017).
Ganesan, A. P. et al. Nat. Immunol. 18, 940–950 (2017).
Savas, P. et al. Nat. Med. 24, 986–993 (2018).
Edwards, J. et al. Clin. Cancer Res. 24, 3036–3045 (2018).
Han, J. et al. Nat. Cancer https://doi.org/10.1038/s43018-021-00180-1 (2021).
Malik, B. T. et al. Sci. Immunol. 2, eaam6346 (2017).
Scott, A. C. et al. Nature 571, 270–274 (2019).
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A.-P.G. is funded by US National Institutes of Health K08 (5K08CA230164-03).
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Ganesan, AP., Ottensmeier, C.H.H. Melanoma-reactive T cells take up residence. Nat Cancer 2, 253–255 (2021). https://doi.org/10.1038/s43018-021-00189-6
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DOI: https://doi.org/10.1038/s43018-021-00189-6
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