Chronic pancreatitis is a risk factor for pancreatic cancer; however, the mechanisms underlying cellular susceptibility to oncogenic transformation are complex. A recent study reports a damage-associated progenitor cell state, controlled by the transcription factors KLF5 and members of the AP-1 family, that initiates tumorigenesis in mouse models of pancreatic cancer in which the proto-oncogene KRAS is altered.
This is a preview of subscription content, log in via an institution to check access.
References
Visvader, J. E. Nature 469, 314–322 (2011).
Haigis, K. M., Cichowski, K. & Elledge, S. J. Science 363, 1150–1151 (2019).
Shema, E., Bernstein, B. E. & Buenrostro, J. D. Nat. Genet. 51, 19–25 (2019).
MacCarthy-Morrogh, L. & Martin, P. Sci. Signal. 13, eaay8690 (2020).
Li, Y. et al. Nat. Cancer https://doi.org/10.1038/s43018-020-00134-z (2020).
Morris, J. P. IV, Cano, D. A., Sekine, S., Wang, S. C. & Hebrok, M. J. Clin. Invest. 120, 508–520 (2010).
Kirkegård, J., Mortensen, F. V. & Cronin-Fenton, D. Am. J. Gastroenterol. 112, 1366–1372 (2017).
Guerra, C. et al. Cancer Cell 11, 291–302 (2007).
Storz, P. Nat. Rev. Gastroenterol. Hepatol. 14, 296–304 (2017).
Kopp, J. L. et al. Cancer Cell 22, 737–750 (2012).
Strobel, O. et al. Gastroenterology 133, 1999–2009 (2007).
Bradner, J. E., Hnisz, D. & Young, R. A. Cell 168, 629–643 (2017).
Collins, M. A. et al. J. Clin. Invest. 122, 639–653 (2012).
Quintanal-Villalonga, Á. et al. Nat. Rev. Clin. Oncol. 17, 360–371 (2020).
Juiz, N. A., Iovanna, J. & Dusetti, N. Front. Oncol. 9, 246 (2019).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
LaFave, L.M., Buenrostro, J.D. Unlocking PDAC initiation with AP-1. Nat Cancer 2, 14–15 (2021). https://doi.org/10.1038/s43018-020-00158-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43018-020-00158-5
- Springer Nature America, Inc.