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IMMUNOTHERAPY

ISACs take a Toll on tumors

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Immunostimulatory agents such as Toll-like receptor (TLR) agonists have shown promising antitumor efficacy but are associated with therapy-related toxicities when delivered systemically. Immune-stimulating antibody conjugates are now shown to deliver TLR agonists with potent preclinical antitumor activities.

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Fig. 1: ISACs: two hits against cancer with one antibody.

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Authors and Affiliations

  1. Innate Pharma Research Laboratories, Innate Pharma, Marseille, France

    Olivier Demaria & Eric Vivier

  2. Aix Marseille University, CNRS, INSERM, CIML, Marseille, France

    Eric Vivier

  3. Assistance Publique des Hôpitaux de Marseille, Hôpital de la Timone, Immunology, Marseille-Immunopôle, Marseille, France

    Eric Vivier

Authors
  1. Olivier Demaria
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  2. Eric Vivier
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Corresponding author

Correspondence to Olivier Demaria.

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Competing interests

O.D. and E.V. are employees of Innate Pharma.

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Demaria, O., Vivier, E. ISACs take a Toll on tumors. Nat Cancer 2, 12–13 (2021). https://doi.org/10.1038/s43018-020-00152-x

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