Metastasis competence can be acquired early in tumorigenesis, although its underlying molecular intricacies remain unclear. A recent study provides key information about the function of L1CAM in conferring metastasis-initiation potential and chemoresistance in colorectal cancer by hijacking epithelial regenerative mechanisms.
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Pascual, G., Benitah, S.A. L1CAM links regeneration to metastasis. Nat Cancer 1, 22–24 (2020). https://doi.org/10.1038/s43018-019-0014-x
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DOI: https://doi.org/10.1038/s43018-019-0014-x
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