Skip to main content
Log in

Circadian rhythms

Maternal rhythms suppress neonatal inflammation

  • News & Views
  • Published:

From Nature Metabolism

View current issue Submit your manuscript

Maternal circadian rhythms influence the health of infants. Cui, Xu and colleagues find that disruption of maternal rhythms impairs neonatal immune cell function and aggravates neonatal inflammatory disorders, which can be rescued by the administration of docosahexaenoic acid (a metabolite found in breast milk).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: DHA in breast milk links maternal circadian rhythms to neonatal immune responses.

References

  1. Wang, C., Lutes, L. K., Barnoud, C. & Scheiermann, C. Sci. Immunol. 7, eabm2465 (2022).

    Article  CAS  PubMed  Google Scholar 

  2. Logan, R. W. & McClung, C. A. Nat. Rev. Neurosci. 20, 49–65 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Henneke, P., Kierdorf, K., Hall, L. J., Sperandio, M. & Hornef, M. eLife 10, e67793 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Gensollen, T., Iyer, S. S., Kasper, D. L. & Blumberg, R. S. Science 352, 539–544 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Simonsen, K. A., Anderson-Berry, A. L., Delair, S. F. & Davies, H. D. Clin. Microbiol. Rev. 27, 21–47 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Astiz, M. et al. Nat. Commun. 11, 3593 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Cui, Z. et al. Nat. Metab. https://doi.org/10.1038/s42255-024-01021-y (2024).

    Article  PubMed  Google Scholar 

  8. Rohwedder, I. et al. JCI Insight 8, e155968 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  9. He, Y. M. et al. Nat. Med. 24, 224–231 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Pick, R., He, W., Chen, C. S. & Scheiermann, C. Trends Immunol. 40, 524–537 (2019).

    Article  CAS  PubMed  Google Scholar 

  11. Gómez-Ferrer, M. et al. Front. Immunol. 14, 1293737 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Xia, S. et al. Cancer Immunol. Immunother. 63, 663–673 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Kervezee, L., Cuesta, M., Cermakian, N. & Boivin, D. B. Proc. Natl Acad. Sci. USA 115, 5540–5545 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Thai, J. D. & Gregory, K. E. Nutrients 12, 581 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christoph Scheiermann.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, X., Sperandio, M. & Scheiermann, C. Maternal rhythms suppress neonatal inflammation. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01027-6

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s42255-024-01027-6

  • Springer Nature Limited

Navigation