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Bone metabolism

Serine synthesis promotes bone degradation

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Bone resorption by osteoclasts requires tight control, as overactivation reduces bone mass and strength. Stegen et al. demonstrate that α-ketoglutarate produced during serine synthesis promotes osteoclast development via metabolic–epigenetic coupling and could be a therapeutic target.

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Fig. 1: Serine metabolism promotes osteoclastogenesis through epigenetic remodelling.

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Acknowledgements

Work in the laboratory of R.C.R. is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (DK099134) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR077533) of the National Institutes of Health as well as the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development (BX003724).

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Authors and Affiliations

  1. Division of Musculoskeletal Science, Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA

    Ryan C. Riddle & Gillian M. Choquette

  2. Research and Development Service, Baltimore VA Medical Center, Baltimore, MD, USA

    Ryan C. Riddle

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  1. Ryan C. Riddle
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  2. Gillian M. Choquette
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Correspondence to Ryan C. Riddle.

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The authors declare no competing interests.

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Riddle, R.C., Choquette, G.M. Serine synthesis promotes bone degradation. Nat Metab 6, 8–9 (2024). https://doi.org/10.1038/s42255-023-00949-x

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