Skip to main content
SpringerLink
Log in

Neuroscience

Linking neuropsychiatric disease to neuronal metabolism

  • News & Views
  • Published:

From Nature Metabolism

View current issue Submit your manuscript

Stress is an important risk factor for neuropsychiatric disorders such as major depression, but the underlying biological mechanisms remain largely unclear. A recent study has revealed a mechanism that regulates neuronal metabolism and mitochondrial function, and thereby drives stress susceptibility and disease outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Stress susceptibility through mitochondrial neuronal metabolism.

References

  1. GBD 2019 Mental Disorders Collaborators. Lancet Psychiatry 9, 137–150 (2022).

    Article  PubMed Central  Google Scholar 

  2. Dong, W.-T. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00924-6 (2023).

    Article  PubMed  Google Scholar 

  3. Picard, M., McEwen, B. S., Epel, E. S. & Sandi, C. Front. Neuroendocrinol. 49, 72–85 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Ghosal, S. et al. Cell Rep 42, 112776 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Hollis, F., Pope, B. S., Gorman-Sandler, E. & Wood, S. K. in Neuroscience of Social Stress (eds Miczek, K. A. & Sinha, R.) 59–93 (Springer International, 2022).

  6. Howard, D. M. et al. Nat. Neurosci. 22, 343–352 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. von Mücke-Heim, I.-A. et al. Mol. Psychiatry 28, 329–340 (2023).

    Article  Google Scholar 

  8. Ayash, S. et al. Proc. Natl Acad. Sci. USA 120, e2205576120 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Bordes, J. et al. Nat. Commun. 14, 4319 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kaluve, A. M., Le, J. T. & Graham, B. M. Neurosci. Biobehav. Rev. 143, 104962 (2022).

    Article  PubMed  Google Scholar 

  11. van Doeselaar, L. et al. Stress 24, 168–180 (2021).

    Article  PubMed  Google Scholar 

  12. Kuehner, C. Lancet Psychiatry 4, 146–158 (2017).

    Article  PubMed  Google Scholar 

  13. Bangasser, D. A. & Cuarenta, A. Nat. Rev. Neurosci. 22, 674–684 (2021).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany

    Mathias V. Schmidt

Authors
  1. Mathias V. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mathias V. Schmidt.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schmidt, M.V. Linking neuropsychiatric disease to neuronal metabolism. Nat Metab 5, 2041–2042 (2023). https://doi.org/10.1038/s42255-023-00929-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-023-00929-1

  • Springer Nature Limited

Search

Navigation