Skip to main content
Log in

Thyroid metabolism

The thyroid gland under Notch control

  • News & Views
  • Published:

From Nature Metabolism

View current issue Submit your manuscript

A study in Nature Metabolism shows that the thyroid gland contains two subtypes of thyrocytes (the cells that produce thyroid hormones) and reveals a role for Notch signalling in regulating thyrocyte homeostasis and activity, as reduced Notch activity results in hypothyroidism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: A role for Notch signalling in the thyroid.

References

  1. Taylor, P. N. et al. Nat. Rev. Endocrinol. 14, 301–316 (2018).

    Article  PubMed  Google Scholar 

  2. Mosteiro, L. et al. Nat Metab. https://doi.org/10.1038/s42255-023-00937-1 (2023).

    Article  Google Scholar 

  3. Bray, S. J. Nat. Rev. Mol. Cell Biol. 17, 722–735 (2016).

    Article  CAS  PubMed  Google Scholar 

  4. Ferretti, E. et al. J. Clin. Endocrinol. Metab. 93, 4080–4087 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. Porazzi, P. et al. Endocrinology 153, 5645–5658 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. Gillotay, P. et al. EMBO Rep. 21, e50612 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Marelli, F., Rurale, G. & Persani, L. Front. Endocrinol. 12, 664557 (2021).

    Article  Google Scholar 

  8. de Filippis, T. et al. Hum. Mol. Genet. 26, 2507–2514 (2017).

    Article  PubMed  Google Scholar 

  9. de Filippis, T. et al. J. Clin. Endocrinol. Metab. 101, 861–870 (2016).

    Article  PubMed  Google Scholar 

  10. Marelli, F. & Persani, L. J. Endocrinol. Invest. 41, 75–81 (2018).

    Article  CAS  PubMed  Google Scholar 

  11. Ayoub, M. D. & Kamath, B. M. Clin. Liver Dis. 26, 355–370 (2022).

    Article  PubMed  Google Scholar 

  12. Landor, S. K.-J. et al. Proc. Natl Acad. Sci. USA 108, 18814–18819 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Romitti, M. et al. Front. Endocrinol. 12, 657195 (2021).

    Article  Google Scholar 

Download references

Acknowledgements

The research in the author’s laboratory is financed by project grants from the Swedish Research Council (2019:00285), the Swedish Cancer Society (4-370/2019), the Swedish Brain Foundation (F2020-0246) and the Erling-Persson Family Foundation. The funders had no role in decision to publish or prepare this work.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Urban Lendahl.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lendahl, U. The thyroid gland under Notch control. Nat Metab 5, 2037–2038 (2023). https://doi.org/10.1038/s42255-023-00911-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-023-00911-x

  • Springer Nature Limited

Navigation