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T cell metabolism

Glutarate tunes T cell fate

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In this issue of Nature Metabolism, a study shows that glutarate increases memory T cells as well as T cell cytotoxicity and reduces tumour growth. During T cell activation, glutarate levels and glutarylation increase. Glutarate inhibits α-ketoglutarate-dependent dioxygenases, and glutarylation reduces pyruvate dehydrogenase complex activity and enhances glycolysis.

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Fig. 1: Scheme depicting how glutarate and the enantiomers of 2-hydroxyglutarate (2HG) affect T cell phenotypes, α-KG-dependent dioxygenases and energy metabolism.

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Authors and Affiliations

  1. DKTK Metabolic Crosstalk in Cancer, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Francisco Yanqui-Rivera & Christiane A. Opitz

  2. Faculty of Bioscience, Heidelberg University, Heidelberg, Germany

    Francisco Yanqui-Rivera

  3. Neurology Clinic and National Center for Tumor Diseases, Heidelberg, Germany

    Christiane A. Opitz

Authors
  1. Francisco Yanqui-Rivera
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  2. Christiane A. Opitz
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Correspondence to Christiane A. Opitz.

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The authors declare no competing interests.

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Yanqui-Rivera, F., Opitz, C.A. Glutarate tunes T cell fate. Nat Metab 5, 1649–1651 (2023). https://doi.org/10.1038/s42255-023-00878-9

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  • DOI: https://doi.org/10.1038/s42255-023-00878-9

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