Okreglak et al. explore the molecular mechanisms that link organellar pH dynamics with the cell cycle, and find that vacuolar pH oscillates during cell cycle phases to ensure an adequate supply of amino acids during cell division. This study offers metabolic insight into the fundamental mechanisms that couple amino acid availability to the cell cycle through pH fluctuations.
References
Webb, B. A., Chimenti, M., Jacobson, M. P. & Barber, D. L. Nat. Rev. Cancer 11, 671–677 (2011).
Orij, R. et al. Genome Biol. 13, R80 (2012).
Okreglak, V. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00872-1 (2023).
Li, S. C. & Kane, P. M. Biochim. Biophys. Acta 1793, 650–663 (2008).
Zoncu, R. et al. Science 334, 678–683 (2011).
Bridges, D. et al. Mol Biol Cell 23, 2955–2962 (2012).
Li, S. C. et al. Mol. Biol. Cell 25, 1251–1262 (2014).
Jin, N., Jin, Y. & Weisman, L. S. J. Cell Biol. 216, 2075–2090 (2017).
Bodzęta, A., Kahms, M. & Klingauf, J. Cell Rep. 20, 1348–1359 (2017).
Watanabe, Y. et al. J. Biol. Chem. 287, 31681–31690 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Kane, P.M. A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle. Nat Metab 5, 1652–1653 (2023). https://doi.org/10.1038/s42255-023-00875-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-023-00875-y
- Springer Nature Limited