Mao et al. discover that heart failure-associated metabolic derangement results in cardiomyocyte cholesterol overload and accumulation of bile acid intermediates, which in turn trigger mitochondrial damage and inflammatory activation and thus promote heart failure.
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Tong, D., Hill, J.A. Bile acid binds heart failure and inflammation. Nat Metab 5, 1260–1261 (2023). https://doi.org/10.1038/s42255-023-00836-5
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DOI: https://doi.org/10.1038/s42255-023-00836-5
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