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Drug metabolism

Gut bacteria thwart the blood sugar-lowering effect of acarbose

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In this issue of Nature Metabolism, a gut bacterial glucosidase that degrades the antidiabetic drug acarbose is linked to poor treatment response. Its widespread distribution in the human microbiome could compromise the efficacy of acarbose treatment in many patients.

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Fig. 1: Unraveling the mechanism of Apg-mediated reduction in the efficacy of acarbose treatment.

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Authors and Affiliations

  1. Interfaculty Institute of Microbiology and Infection Medicine Tübingen, University of Tübingen, Tübingen, Germany

    Melanie M. Brauny & Lisa Maier

  2. Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany

    Melanie M. Brauny & Lisa Maier

Authors
  1. Melanie M. Brauny
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  2. Lisa Maier
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Correspondence to Lisa Maier.

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The authors declare no competing interests.

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Brauny, M.M., Maier, L. Gut bacteria thwart the blood sugar-lowering effect of acarbose. Nat Metab 5, 732–734 (2023). https://doi.org/10.1038/s42255-023-00798-8

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