Glycolysis provides building blocks for the proinflammatory activation of macrophages and simultaneously generates pyruvate. In this issue of Nature Metabolism, Ran et al. provide evidence that the transport of pyruvate to fuel the Krebs cycle in the mitochondria is not required in the inflammatory response.
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References
O’Neill, L. A. J. & Pearce, E. J. J. Exp. Med. 213, 15–23 (2016).
Ran, L. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00800-3 (2023).
Mehta, M. M., Weinberg, S. E. & Chandel, N. S. Nat. Rev. Immunol. 17, 608–620 (2017).
Palmieri, E. M. et al. Nat. Commun. 11, 698 (2020).
Jha, A. K. et al. Immunity 42, 419–430 (2015).
Lauterbach, M. A. et al. Immunity 51, 997–1011 (2019).
Bae, S. et al. Cell Rep. 35, 109264 (2021).
Langston, P. K. et al. Nat. Immunol. 20, 1186–1195 (2019).
Zhu, B. et al. Sci. Immunol. https://doi.org/10.1126/sciimmunol.adf0348 (2023).
Divakaruni, A. S. et al. Cell Metab. 28, 490–503 (2018).
Faubert, B. et al. Cell 171, 358–371 (2017).
Yang, C. et al. Mol. Cell 56, 414–424 (2014).
Merlin, J. et al. Nat. Metab. 3, 1313–1326 (2021).
Morioka, S. et al. Nature 563, 714–718 (2018).
Schilperoort, M., Ngai, D., Katerelos, M., Power, D. A. & Tabas, I. Nat. Metab. 5, 431–444 (2023).
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L.Y.-C. and E.B.T. declare no competing interests.
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Yvan-Charvet, L., Thorp, E.B. Inflamed macrophages sans mitochondrial pyruvate carrier?. Nat Metab 5, 724–726 (2023). https://doi.org/10.1038/s42255-023-00789-9
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DOI: https://doi.org/10.1038/s42255-023-00789-9
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