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Lipid homeostasis

Asters: rising stars in the cholesterol universe

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Intracellular trafficking of cholesterol is essential for its uptake, storage and export. In this issue of Nature Metabolism, Xiao et al. provide powerful evidence for the importance of hepatic GRAMD1/Aster transporters in maintaining systemic cholesterol homeostasis.

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Fig. 1: Role of Aster proteins in mouse hepatic cholesterol transport.

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Acknowledgements

The Brown Laboratory is supported by an Australian Research Council Discovery Project Grant DP170101178. H.W.C. is in receipt of a UNSW Science Writing Scholarship.

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  1. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia

    Hudson W. Coates & Andrew J. Brown

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  1. Hudson W. Coates
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  2. Andrew J. Brown
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Correspondence to Andrew J. Brown.

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The authors declare no competing interests.

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Coates, H.W., Brown, A.J. Asters: rising stars in the cholesterol universe. Nat Metab 5, 16–18 (2023). https://doi.org/10.1038/s42255-022-00717-3

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