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Metabolic compartmentalization

BCAT2–BCKDH metabolon maintains BCAA homeostasis

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BCAA homeostasis is crucial to human health. A new study demonstrates that a mitochondrial metabolon assembled by BCAT2 and BCKDH controls BCAA metabolism in vivo, providing opportunities to develop strategies for repairing dysfunctional BCAA homeostasis.

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Fig. 1: The BCAT2–BCKDH metabolon drives BCAA metabolism, preventing accumulation of BCAA and BCKA.

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Authors and Affiliations

  1. Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences, Cancer Institutes, School of Basic Medical Sciences, Key Laboratory of Breast Cancer in Shanghai, Shanghai Key Laboratory of Radiation Oncology, The Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University, Shanghai, China

    Miao Yin & Qun-Ying Lei

  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

    Miao Yin & Qun-Ying Lei

Authors
  1. Miao Yin
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  2. Qun-Ying Lei
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Correspondence to Miao Yin or Qun-Ying Lei.

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Yin, M., Lei, QY. BCAT2–BCKDH metabolon maintains BCAA homeostasis. Nat Metab 4, 1618–1619 (2022). https://doi.org/10.1038/s42255-022-00680-z

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