Skip to main content
SpringerLink
Log in

SPATIAL METABOLOMICS

Zooming in on kidney metabolism

  • News & Views
  • Published:

From Nature Metabolism

View current issue Submit your manuscript

Mass spectrometry imaging holds promise for mapping the intricate organization of metabolism in complex tissues. Wang et al. combine this exciting technique with metabolic tracing ex vivo to uncover metabolic specialization and adaptation in the mouse kidney.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Principle of spatial metabolic tracing ex vivo using MSI.

References

  1. Weidemann, M. J. & Krebs, H. A. Biochem. J. 112, 149–166 (1969).

    Article  CAS  Google Scholar 

  2. Kean, E. L. et al. Biochim. Biophys. Acta 54, 474–478 (1961).

    Article  CAS  Google Scholar 

  3. Wang, G. Nat. Metab. https://doi.org/10.1038/s42255-022-00615-8 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Buchberger, A. R. et al. Anal. Chem. 90, 240–265 (2018).

    Article  CAS  Google Scholar 

  5. Gilmore, I. S., Heiles, S. & Pieterse, C. L. Annu. Rev. Anal. Chem. 12, 201–224 (2019).

    Article  CAS  Google Scholar 

  6. Jang, C., Chen, L. & Rabinowitz, J. D. Cell 173, 822–837 (2018).

    Article  CAS  Google Scholar 

  7. Sugiura, Y. et al. Sci. Rep. 6, 32361 (2016).

    Article  CAS  Google Scholar 

  8. Arts, M. et al. Angew. Chem. Int. Ed. 56, 7146–7150 (2017).

    Article  CAS  Google Scholar 

  9. Wang, L. et al. Nat. Methods 19, 223–230 (2022).

    Article  CAS  Google Scholar 

  10. Grima-Reyes, M. et al. Molec. Metab. 53, 101294 (2021).

    Article  CAS  Google Scholar 

  11. Antoniewicz, M. R. Exp. Mol. Med. 50, 1–13 (2018).

    Article  CAS  Google Scholar 

  12. Bigaeva, E. et al. Arch. Toxicol. 93, 3549–3583 (2019).

    Article  CAS  Google Scholar 

  13. Cantor, J. R. et al. Cell 169, 258–272 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Roland Nilsson

  2. Division of Cardiovascular Medicine, Karolinska University Hospital, Stockholm, Sweden

    Roland Nilsson

  3. Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

    Roland Nilsson

Authors
  1. Roland Nilsson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Roland Nilsson.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nilsson, R. Zooming in on kidney metabolism. Nat Metab 4, 1089–1090 (2022). https://doi.org/10.1038/s42255-022-00621-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-022-00621-w

  • Springer Nature Limited

Search

Navigation