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Cellular metabolism

GAPDH redox redux—rewiring pentose phosphate flux

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GAPDH is highly sensitive to oxidation by reactive oxygen species, but how exactly its oxidation alters carbon flux is not known. Talwar et al. demonstrate that oxidative inactivation of GAPDH is required for maximal pentose phosphate pathway flux to support NADPH generation during oxidative stress.

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Fig. 1: GAPDH inactivation and G6PD de-inhibition act in concert to divert the flux of glucose into the PPP under oxidative stress conditions.

Change history

  • 14 April 2023

    In the version of this article initially published, there were errors in cited research names, where the three instances of Talwar et al. originally referred to Rechmann et al.; the updates are made in the HTML and PDF versions of the article.

References

  1. Harris, I. S. & DeNicola, G. M. Trends Cell Biol. 30, 440–451 (2020).

    Article  CAS  PubMed  Google Scholar 

  2. Ralser, M. et al. J. Biol. 6, 10 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kuehne, A. et al. Mol. Cell 59, 359–371 (2015).

    Article  CAS  PubMed  Google Scholar 

  4. Ozer, N., Aksoy, Y. & Ogüs, I. H. Int. J. Biochem. Cell Biol. 33, 221–226 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. Christodoulou, D. et al. iScience 19, 1133–1144 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Anastasiou, D. et al. Science 334, 1278–1283 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Peralta, D. et al. Nat. Chem. Biol. 11, 156–163 (2015).

    Article  CAS  PubMed  Google Scholar 

  8. Talwar, D. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00781-3 (2023).

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Authors and Affiliations

  1. Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA

    Laura Torrente & Gina M. DeNicola

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  1. Laura Torrente
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  2. Gina M. DeNicola
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Correspondence to Gina M. DeNicola.

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The authors declare no competing interests.

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Torrente, L., DeNicola, G.M. GAPDH redox redux—rewiring pentose phosphate flux. Nat Metab 5, 538–539 (2023). https://doi.org/10.1038/s42255-021-00523-3

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