A recent study shows how hyperinsulinaemia in obesity unexpectedly activates the cell cycle of overworked mature adipocytes in a process known as endo-reduplication, which represents a ‘last gasp’ strategy to remain functionally competent. However, this strategy fails and triggers premature senescence and tissue dysfunction.
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Rodriguez-Cuenca, S., Vidal-Puig, A. Insulin and the last gasp of failing adipocytes. Nat Metab 3, 1443–1444 (2021). https://doi.org/10.1038/s42255-021-00492-7
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DOI: https://doi.org/10.1038/s42255-021-00492-7
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