Lipolysis generates fatty acids that are burned in peroxisomes for energy, and dysregulation in this process creates toxic reactive oxygen species (ROS) and contributes to diseases such as non-alcoholic fatty liver disease. In this issue of Nature Metabolism, Ding et al. reveal how the peroxin PEX2 senses cellular ROS to fine-tune ATGL-mediated lipolysis.
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Acknowledgements
The authors apologize for any references omitted owing to space constraints. This work was supported by funds from the Welch Foundation (I-1873), the NIH NIGMS (GM119768), NIDDK (DK126887) and the UTSW Endowed Scholars Program.
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Paul, B., Henne, W.M. How cells flex their PEX to fine-tune lipolysis in NAFLD. Nat Metab 3, 1591–1593 (2021). https://doi.org/10.1038/s42255-021-00490-9
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DOI: https://doi.org/10.1038/s42255-021-00490-9
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