Over-nutrition is a major driver of obesity, but the mechanisms that promote and perpetuate it remain poorly understood. A recent study explores a role for umami taste in driving leptin resistance, hyperphagia and hypothalamic inflammation via overproduction of uric acid.
References
Rossi, M. A. & Stuber, G. D. Cell Metab. 27, 42–56 (2018).
Andres-Hernando, A. et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00454-z (2021).
Hannou, S. A., Haslam, D. E., McKeown, N. M. & Herman, M. A. J. Clin. Invest. 128, 545–555 (2018).
Maffei, M. et al. Proc. Natl Acad. Sci. USA 92, 6957–6960 (1995).
Myers, M. G. Jr., Leibel, R. L., Seeley, R. J. & Schwartz, M. W. Trends Endocrinol. Metab. 21, 643–651 (2010).
Knight, Z. A., Hannan, K. S., Greenberg, M. L. & Friedman, J. M. PLoS One 5, e11376 (2010).
Zhao, S. et al. Cell Metab. 30, 706–719.e6 (2019).
Thaler, J. P. et al. J. Clin. Invest. 122, 153–162 (2012).
Lu, W. et al. Sci. Rep. 5, 12144 (2015).
Denis, R. G. et al. Cell Metab. 22, 646–657 (2015).
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Beutler, L.R. Umami taste—a novel mechanism driving food intake and obesity. Nat Metab 3, 1142–1143 (2021). https://doi.org/10.1038/s42255-021-00445-0
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DOI: https://doi.org/10.1038/s42255-021-00445-0
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