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A spoonful of DHAP keeps mTORC1 running on sugars

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The mechanistic target of rapamycin complex 1 (mTORC1) network integrates nutrient and energy signals that regulate metabolism and cell growth. Orozco et al. now show that the glycolytic intermediate dihydroxyacetone phosphate (DHAP) relays glycolytic activity to mTORC1 signalling.

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Fig. 1: DHAP sensing by mTORC1.

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Authors and Affiliations

  1. Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Gerta Hoxhaj

  2. Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA

    Jason W. Locasale

  3. Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, USA

    Jason W. Locasale

  4. Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA

    Issam Ben-Sahra

Authors
  1. Gerta Hoxhaj
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  2. Jason W. Locasale
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  3. Issam Ben-Sahra
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Corresponding authors

Correspondence to Gerta Hoxhaj, Jason W. Locasale or Issam Ben-Sahra.

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The authors declare no competing interests.

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Hoxhaj, G., Locasale, J.W. & Ben-Sahra, I. A spoonful of DHAP keeps mTORC1 running on sugars. Nat Metab 2, 801–802 (2020). https://doi.org/10.1038/s42255-020-0246-1

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  • DOI: https://doi.org/10.1038/s42255-020-0246-1

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