The adipose tissue harbours multiple immune-cell types whose populations are known to be altered in disease conditions. A new study by Brigger et al. shows that restocking fat tissues of old mice with eosinophils prevents age-related declines in physical and immunological functions.
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References
Conboy, I. M. & Rando, T. A. Cell Cycle 11, 2260–2267 (2012).
Pérez, L. M. et al. J. Physiol. (Lond.) 594, 3187–3207 (2016).
McNelis, J. C. & Olefsky, J. M. Immunity 41, 36–48 (2014).
Brigger, D. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-0228-3 (2020).
Villeda, S. A. et al. Nature 477, 90–94 (2011).
Brestoff, J. R. & Artis, D. Cell 161, 146–160 (2015).
Wu, D. et al. Science 332, 243–247 (2011).
Heredia, J. E. et al. Cell 153, 376–388 (2013).
Molofsky, A. B. et al. J. Exp. Med. 210, 535–549 (2013).
Fabbiano, S. et al. Cell Metab. 24, 434–446 (2016).
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Lee, CH. Young eosinophils rejuvenate ageing adipose tissues. Nat Metab 2, 655–656 (2020). https://doi.org/10.1038/s42255-020-0230-9
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DOI: https://doi.org/10.1038/s42255-020-0230-9
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