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NAD METABOLISM

NAD on the rise again

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Maintaining cellular NAD levels through supplementation with intermediates of NAD synthesis has considerable health benefits. A new study demonstrates that the reduced form of nicotinamide riboside, NRH, can be converted to NAD in a biosynthetic pathway that involves adenosine kinase, thus strongly boosting NAD levels in cells and tissues.

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Fig. 1: NRH enters NAD synthesis through AK and boosts NAD-dependent metabolism and signalling.

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Acknowledgements

M.Z. was supported by the Norwegian Research Council and the Norwegian Cancer Society. A.A.N. was supported by the Program for Molecular and Cell Biology and Post-Genomic Technologies of the Russian Academy of Sciences.

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Authors and Affiliations

  1. Department of Biomedicine, University of Bergen, Bergen, Norway

    Mathias Ziegler

  2. Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia

    Andrey A. Nikiforov

Authors
  1. Mathias Ziegler
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  2. Andrey A. Nikiforov
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Correspondence to Mathias Ziegler or Andrey A. Nikiforov.

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The authors declare no competing interests.

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Ziegler, M., Nikiforov, A.A. NAD on the rise again. Nat Metab 2, 291–292 (2020). https://doi.org/10.1038/s42255-020-0197-6

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