A new global measure of cell-to-cell transcriptional variability from single-cell RNA-sequencing data has been developed by Levy et al., on the basis of the transcriptional interrelations between genes. The new variable, termed global coordination level, decreases with age in different organisms and cell types and correlates with high mutational load in cells.
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J.V. is a cofounder of and stock holder in SingulOmics, Corp., USA.
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Vijg, J. Loss of gene coordination as a stochastic cause of ageing. Nat Metab 2, 1188–1189 (2020). https://doi.org/10.1038/s42255-020-00295-2
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DOI: https://doi.org/10.1038/s42255-020-00295-2
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