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OBESITY AND METABOLIC DISEASE

Diving deep—multipronged investigations into RIPK1 as a risk factor for obesity

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A recent study by Karunakaran et al. suggests that RIPK1 is important in obesity and related metabolic traits. With genetic variation associated with expression and the risk of obesity, and repression of activity leading to a favourable metabolic profile in an obesogenic model, is there evidence for a potential therapeutic role?

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Fig. 1: Triangulation of evidence around RIPK1 as a candidate for a role in body-composition-related cellular pathways.

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Acknowledgements

N.J.T. is a Wellcome Trust Investigator (202802/Z/16/Z) and the PI of the Avon Longitudinal Study of Parents and Children (MRC and WT 217065/Z/19/Z); is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011); and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169).

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  1. MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK

    Nicholas John Timpson

  2. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK

    Nicholas John Timpson

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  1. Nicholas John Timpson
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Correspondence to Nicholas John Timpson.

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Timpson, N.J. Diving deep—multipronged investigations into RIPK1 as a risk factor for obesity. Nat Metab 2, 997–998 (2020). https://doi.org/10.1038/s42255-020-00284-5

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