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MACROPHAGE METABOLISM

Targeting macrophage immunometabolism to prevent atherosclerosis

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Di Gioia and colleagues report on how the oxidized phospholipid oxPAPC alters metabolism in macrophages via glutamine and oxaloacetate, thus boosting production of the cytokine IL-1β and promoting atherosclerosis.

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Fig. 1: Macrophage metabolism in response to LPS and oxPAPC.

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Correspondence to Luke A. J. O’Neill.

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O’Neill, L.A.J. Targeting macrophage immunometabolism to prevent atherosclerosis. Nat Metab 1, 1173–1174 (2019). https://doi.org/10.1038/s42255-019-0154-4

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