A study in Nature Metabolism reveals a hitherto-unknown enzymatic and physiological role of ABHD5, which acts as a protease that couples extracellular cues to the epigenome of cardiomyocytes by cleaving histone deacetylase 4 (HDAC4).
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Acknowledgements
T.A.M. was supported by the National Institutes of Health through grants HL116848, HL147558, DK119594 and HL127240. J.G.T. was supported by the National Institutes of Health through grant HL147463. T.A.M. and J.G.T. were supported by the American Heart Association (16SFRN31400013).
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Travers, J.G., McKinsey, T.A. ABHD5 cleaves HDAC4 to benefit the heart. Nat Metab 1, 1034–1035 (2019). https://doi.org/10.1038/s42255-019-0141-9
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DOI: https://doi.org/10.1038/s42255-019-0141-9
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