Nuclear DNA damage has detrimental effects on cellular homoeostasis and accelerates the ageing process. A new study causally links error-prone mitochondrial replication to increased nuclear DNA damage, thus suggesting that the hallmarks of ageing are associated with nuclear genome instability, a potential unifying denominator in the ageing process.
References
Niedernhofer, L. J. et al. Annu. Rev. Biochem. 87, 295–322 (2018).
Trifunovic, A. et al. Nature 429, 417–423 (2004).
Vermulst, M. et al. Nat. Genet. 39, 540–543 (2007).
Hämäläinen, R.H. et al. Nat. Metab. https://doi.org/10.1038/s42255-019-0120-1 (2019).
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Cell 153, 1194–1217 (2013).
Edifizi, D. et al. Cell Rep. 20, 2026–2043 (2017).
Behrens, A., van Deursen, J. M., Rudolph, K. L. & Schumacher, B. Nat. Cell Biol. 16, 201–207 (2014).
Shimizu, I., Yoshida, Y., Suda, M. & Minamino, T. Cell Metab. 20, 967–977 (2014).
Fang, E. F. et al. Trends Mol. Med. 23, 899–916 (2017).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Schumacher, B., Vijg, J. Age is in the nucleus. Nat Metab 1, 931–932 (2019). https://doi.org/10.1038/s42255-019-0125-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-019-0125-9
- Springer Nature Limited