Systemic accumulation of branched-chain amino acids (BCAAs) is a major metabolic hallmark and contributor to insulin resistance associated with obesity. A recent report identifies SLC25A44 as the BCAA transporter in mitochondrial membranes and shows that BCAA catabolism in brown adipose tissue significantly affects thermogenic activity, systemic BCAA clearance, energy expenditure and overall metabolic health.
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Sun, H., Wang, Y. A new branch connecting thermogenesis and diabetes. Nat Metab 1, 845–846 (2019). https://doi.org/10.1038/s42255-019-0112-1
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DOI: https://doi.org/10.1038/s42255-019-0112-1
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