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METABOLIC SYNDROME

Exocrine or endocrine? A circulating pancreatic elastase that regulates glucose homeostasis

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A recent study by Esteghamat et al., published in Nature Genetics, has reported that CELA2A, encoding a pancreatic enzyme, is a novel genetic cause of metabolic syndrome and atherosclerosis.

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Fig. 1: Schematic representation of CELA2A release from the pancreatic exocrine cells and its effects on pancreatic endocrine cells.

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Acknowledgements

A.L.G. is a Wellcome Senior Fellow in Basic Biomedical Science (095101/Z/10/Z and 200837/Z/16/Z). A.L.G. is also supported by the Oxford NIHR Biomedical Research Centre. The views expressed in this article are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health.

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Authors and Affiliations

  1. Oxford Centre for Diabetes Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

    Anna L. Gloyn

  2. Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK

    Anna L. Gloyn

  3. Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK

    Anna L. Gloyn

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  1. Anna L. Gloyn
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Correspondence to Anna L. Gloyn.

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Gloyn, A.L. Exocrine or endocrine? A circulating pancreatic elastase that regulates glucose homeostasis. Nat Metab 1, 853–855 (2019). https://doi.org/10.1038/s42255-019-0107-y

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