The gene encoding the RagC GTPase (RRAGC), an activator of a nutrient-sensing pathway that drives cellular anabolism, is mutated in 15% of follicular lymphoma cases. A new study provides evidence that RRAGC mutations promote lymphomagenesis by distorting the nutrient-dependent control of paracrine signals from the microenvironment, thus enhancing B-cell activation.
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Klein, U. Losing control of nutrient sensing in the germinal centre drives lymphomagenesis. Nat Metab 1, 750–751 (2019). https://doi.org/10.1038/s42255-019-0103-2
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DOI: https://doi.org/10.1038/s42255-019-0103-2
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