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ATHEROSCLEROSIS

The Janus-faced role of SR-BI in atherosclerosis

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The entry of remnants of cholesterol-rich lipoproteins, such as low-density lipoprotein (LDL), from the blood stream into the intima of large arteries initiates and then perpetuates atherosclerosis. A study published in Nature sheds new light on this important process by identifying scavenger receptor BI (SR-BI) as a major receptor that mediates LDL delivery across the endothelium into arteries.

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Fig. 1: The yin and yang of SR-B1 in atherogenesis.

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Authors and Affiliations

  1. Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA

    Xinbo Zhang & Carlos Fernández-Hernando

  2. Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine and Department of Pathology, Yale University School of Medicine, New Haven, CT, USA

    Xinbo Zhang & Carlos Fernández-Hernando

Authors
  1. Xinbo Zhang
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  2. Carlos Fernández-Hernando
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Correspondence to Carlos Fernández-Hernando.

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The authors declare no competing interests.

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Zhang, X., Fernández-Hernando, C. The Janus-faced role of SR-BI in atherosclerosis. Nat Metab 1, 586–587 (2019). https://doi.org/10.1038/s42255-019-0072-5

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