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PHYSIOLOGY

Go with the flow—hidden vascular passages in bone

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The circulatory system in long bones is incompletely understood. A new study published in Nature Metabolism unveils the presence of dense vascular networks in long bones that facilitate the egress of bone marrow cells and potentially the exchange of nutrients between the bone marrow and the systemic circulation.

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Fig. 1: Formation and function of trans-cortical vein canals within compact bone.

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Author information

Authors and Affiliations

  1. Allergy, Immunology and Rheumatology Division, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA

    Christopher Ritchlin

  2. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA

    Iannis E. Adamopoulos

  3. Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, CA, USA

    Iannis E. Adamopoulos

Authors
  1. Christopher Ritchlin
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  2. Iannis E. Adamopoulos
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Corresponding author

Correspondence to Christopher Ritchlin.

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Competing interests

I.A. has received consultancy fees/grants from Pfizer, Schering-Plough/Merck, Tanabe Research Labs, and Novartis. C.R. declares no competing interests.

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Ritchlin, C., Adamopoulos, I.E. Go with the flow—hidden vascular passages in bone. Nat Metab 1, 173–174 (2019). https://doi.org/10.1038/s42255-018-0024-5

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